“I have nothing to hide; it seems my honesty is what people relate to most,” he once told Vintage Guitar magazine. “Anders (Osborne) told me early on, ‘If you don’t believe what you’re singing, you’ll never be a good singer.’ I try not to write fluff; I try to make every word count.”

​Naturally, patience and perseverance have been Zito’s stock and trade since the beginning. He began playing guitar at the age of five, and by the time he reached his late teens, he was already a fixture on the local St. Louis music scene. He initially released his music independently and then signed with Eclecto Groove Records in 2008. “Pearl River,” the title track of his 2009 album for the label, won Song of the Year at the Blues Music Awards and marked his first collaboration with Cyril Neville, with whom he’d later work in the Royal Southern Brotherhood. A steady succession of critically acclaimed albums followed, culminating in 2011’s Greyhound, which was nominated for Best Rock Blues Album at that year’s Blue Music Awards ceremony in Memphis. Two years later, he signed with Ruf Records and released Gone to Texas, the story of how he gained his sobriety, offered an emotional homage to the state that left an indelible imprint on his entire life. It also marked the debut of his band, The Wheel.​

From 2010 to 2014, Zito also played an integral role in the super group of sorts, Royal Southern Brotherhood. The group released two albums and a DVD, Songs from the Road – Live in Germany, winner of the year’s Blues Music Award for Best DVD. He also made his mark behind the boards by producing albums for Samantha Fish, Albert Castiglia, Ally Venable, Jeremiah Johnson, Jimmy Carpenter, and many others.​

Mike Zito’s last CD, Quarantine Blues, was recorded during the heart of the coronavirus pandemic and served as a healing love letter to his fans around the world that heralded better days ahead if we’d all just stick together.  His album prior to that was a tribute to fellow St. Louis native and rock ‘n’ roll legend, Chuck Berry, and featured an array of guest guitarists ranging from Joe Bonamassa, Walter Trout and Eric Gales, to Robben Ford, Luther Dickinson and Sonny Landreth, as well as Berry’s own grandson.